Alan Conlon, a smoker for more than 30 years, took the test.
His advice: Go for it, because you're better off knowing.
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Genetic and environmental basis of lung cancer
Lichtenstein P., et al: Environmental and heritable factors in the causation of cancer: analyses of cohorts of twins from Sweden, Denmark and Finland. N Eng J Med 2000; 343: 78-85.
Xu H., et al: Complex segregation analysis reveals a multigene model for lung cancer. Hum Genet 2005; 116: 121-127.
Shields P., Harris, C: Cancer risk and low-penetrance susceptibility genes in gene-environment interactions. J Clin Oncol 2000; 18: 2309-2315.
Modelling for lung cancer risk
Moskvina V., et al: Design of case-controls studies with unscreened controls. Ann Hum Genet 2005, 69: 566-576.
Bach PB, Katton MW, Thornquist MD, et al. Variation in lung cancer risk among smokers. J Nat Can Inst 2003; 95: 470-478.
Cassidy A., et al: Lung cancer risk prediction: a tool for early detection. Int J Cancer 2006; 120: 1-6.
COPD and lung cancer susceptibility
Brody J.S., Spira, A.: Chronic obstructive pulmonary disease, inflammation, and lung cancer. Proc Am Thorac Soc 2006, 3: 535-538.
Mannino D.M., et al: Low lung function and incident lung cancer in the United States: data from the first NHANES follow-up. Arch Int Med 2003; 163: 1475-1480.
Petty TL. Are COPD and Lung cancer two manifestations of the same disease?. Chest 2005; 128: 1895-1897.
Multi-SNP panels and their clinical utility in predisposition testing
Zheng S.L., et al: Cumulative association of five genetic variants with prostate cancer. NEJM 2008, 358: 910-919.
Wald N.J., et al: When can a risk factor be used as a worthwhile screening test?. Brit Med J 1999; 319: 1562-1565.
Xu H., et al: Complex segregation analysis reveals a multigene model for lung cancer. Hum Genet 2005; 116: 121-127.
SNP associations with lung cancer
Juul K, et al. Genetically increased antioxidative protection and decreased COPD. Am J Respir Crit Care Med 2006; 173: 858-864.
Hung RJ, et al. International lung cancer consortium: Pooled analysis of sequence variants in DNA repair and cell cycle pathways. Can Epidemiol Bio Prev 2008; 17: 3081-3089.
Wikman H., et al: Relevance of N-acetyltransferase 1 and 2 (NAT1,NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility. Pharmacogenetics 2001; 11: 157-168.
Genetic testing and smoking cessation
Lerman C., et al: Incorporating biomarkers of exposure and genetic susceptibility into smoking cessation treatment: effects on smoking-related cognitions, emotions and behavior change. Health Psychology 1997; 16: 87-99.
Strange C., et al: Genetic testing for alpha1-antitrypsin deficiency. Genet Med 2004; 6: 204-210.
Utility of genetic testing for lung cancer and early diagnosis
Hamilton W., et al: What are the clinical features of lung cancer before the diagnosis is made? A population based case-control study. Thorax 2005; 60: 1059-1067.
Koyi H, Hillerdal G, Brandon E. Patient’s and doctor’s delays in the diagnosis of chest tumors. Lung Cancer 2002; 35: 53-57.
Factors reducing the risk of lung cancer – Possible Benefits from Statin Therapy
Khurana V, Bejjanki HR, Caldito G, Owens MW. Statins Reduce the Risk of Lung Cancer in Humans: A Large Case-Control Study of US Veterans. Chest 2007; 131: 1282-1288.
Young, Robert P. and Raewyn J. Hopkins. Statins Use and Pneumonia. Chest May 2010 137:1249.
Young, Robert P. and Raewyn J. Hopkins. Possible role of Statins in COPD-related Pulmonary Hypertension. Chest May 2010 137:1250-1251.